If Listing Sync Pro is active, the syncing process will not stop until the billing cycle comes to an end, (even when the product has been canceled).
To stop the sync immediately, you will need to first cancel the product, then click the "force deactivation" button from the kebab menu.
If Listing Sync Pro is not activated, simply toggle the "Sync" switch to 'off' under Listing Builder > Listing Sync.
Please note that since Facebook and Instagram are closely linked, toggling the Facebook switch off will also toggle it off for Instagram.